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albicans GPX with a significant antioxidant contribution, we wanted to determine if the phenotype for the gpxΔ/Δ/Δ/Δ and gpx3Δ/Δ strains was a result of a failure of the GPxs to act on peroxides or if it was possibly due to a defect in Cap1 activation
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For example, the reduction of pyruvate to lactate, as catalyzed by lactate dehydrogenase, is accompanied by the oxidation of NADH to NAD + , as shown in the following two half-reactions: To evaluate the driving force for the full reaction to occur, one would consider the standard reduction potential, E°, associated with each of the individual half reactions
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