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Furthermore, Fe 2 O 3 NPs can generate ROS from the Fenton reaction on their surface, leading to cytotoxic effects (Voinov et al., 2011

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48,49 For its catalytic activity 5-LOX requires a 5-LOX-activating protein (FLAP), 50,51 a membrane-spanning protein with three transmembrane domains belonging to the “membrane-associated proteins in eicosanoid and glutathione metabolism (MAPEG)” family that includes LTC4 synthase and microsomal PGE2 synthase