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If transport is dysfunctional (e.g., reduced EAAT expression or inhibition of activity), glutamate overaccumulation can trigger receptor overactivation, leading to neuroinflammation, mitochondrial dysfunction, and oxidative stress cascades, ultimately triggering excitotoxicity—a mechanism that has been implicated in epilepsy, PD, ALS, and AD, among other neurodegenerative diseases [111, 112, 113]
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Size x Gauge x Needle Length:3cc 20g x 1 1/2"
Membrane capacitance (C m ) and series resistance (R s ) were measured automatically by the EPC-9 “cap.track” feature, based on the “time domain” technique (Lindau and Neher, 1988) and the use of an algorithm described by Sigworth et al
