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Abbreviations ACE2: Angiotensin converting enzyme 2 BBB: Blood-brain barrier CDO: Cysteine dioxygenase COVID-19: Coronavirus disease 2019 CSE: Cystathionine- γ -lyase Cys: Cysteine ER: Endoplasmic reticulum En: Endothelial EnGL: Endothelial glycocalyx Ep: Epithelial EpGL: Epithelial glycocalyx GAG: Glycosaminoglycan GL: Glycocalyx GSH: Glutathione G6PD: Glucose-6-phosphate dehydrogenase HPSE: Heparanase HS: Heparan sulfate HSPG: Heparan sulfate proteoglycan HCQ: Hydroxychloroquine HSA: Human serum albumin H 2 S: Hydrogen sulfide IL: Interleukin IV: Intravenous Met: Methionine MPO: Myeloperoxidase MSM: Methylsulfonylmethane NAC: N-acetylcysteine NF- κ B: Nuclear transcription factor kappa B PGs: Proteoglycans ROS: Reactive oxygen species SAA: Sulfur amino acid SARS-CoV-2: Severe acute respiratory syndrome–related coronavirus 2 SOD: Superoxide dismutase SP: Spike protein STS: Sodium thiosulfate PAPS: Sulfonucleotide 3-phosphoadenosine 5-phosphosulfate ST or SULT: Sulfotransferase TNF α : Tumour necrosis factor α

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