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Similar to the findings in patients with AD, the expression levels of APP-Kla were significantly decreased in the hippocampus and cortex tissues of 6-month-old APP23/PS45 double-transgenic AD model mice compared with age-matched WT mice (Figure 1, E–H)

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Long‐term use of levodopa frequently leads to debilitating motor complications, such as motor fluctuations (wearing‐off phenomena) and levodopa‐induced dyskinesias, attributed to pulsatile dopamine receptor stimulation and adaptive neural circuit changes [61, 86, 87]