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The drug slows turnover of skin cells by inhibiting the metabolism of folate, a B vitamin necessary for normal cell metabolism, differentiation, and division (Bailey 1999

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170 In a randomized placebo-controlled trial involving 102 healthy individuals, 600 mg valerian extract an hour before bedtime did not cause morning sleepiness, poor concentration, or reduced reaction time after a single use or nightly use for two weeks, confirming the safety of valerian in healthy people