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[DOI] [PMC free article] [PubMed] [Google Scholar] 196.Metzger R., Bohle R.M., Pauls K., Eichner G., Alhenc-Gelas F., Danilov S.M., et al
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Increased intracellular Ca 2+ activates Ca 2+ -dependent K + channels (Gardos channels), promoting K + efflux and cell shrinkage, while also stimulating scramblases that drive PS externalization ( In vitro , iron chelation with deferoxamine mimics these effects, inducing dose-dependent eryptosis in human erythrocytes, confirming iron depletion per se primes RBCs for apoptotic death (Turpin et al., 2021