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In patients with coronary artery disease, a 2018 meta-analysis of eight RCTs reported the effects of supplementation on lowering total cholesterol and increasing high-density lipoprotein-cholesterol levels, but no changes in low-density lipoprotein-cholesterol and lipoprotein(a) levels [123]

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More than 90% of participants reported that the stimulation on the tongue was set at a comfortable level during fitting ( Figure 5c )