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For example, although individually CDK4/6 inhibitors and PI3K inhibitors have little effect in a mouse model of triple negative breast cancer, the combination of CDK4/6 and PI3K inhibitors increases the expression of HLA antigens leading to an increase in tumor-infiltrating cytotoxic CD4 + and CD8 + T cells and natural killer cells, and a decrease in the CD4 + FOXP3 + Treg suppressor cells (Teo et al., 2017)

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