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If you are low or deficient in magnesium, increasing your intake of magnesium-rich foods or supplementing with magnesium may help to stabilize your mast cells.[ref] Additionally, histamine release from mast cells has been shown to decrease cellular magnesium levels, making it more likely that someone with histamine-related problems would need additional magnesium.[ref] Related article : Magnesium absorption, transport, and deficiency genes Vitamin B6 (P5P) and copper: Vitamin B6 and copper are both cofactors in the reactions that degrade histamine.[ref] Pyridoxal-5′-phosphate is the active form of vitamin B6