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52 In 2023, the Nobel Prize in Physiology and Medicine was awarded to Katalin Kariko and Drew Weissman for pioneering nucleoside base modification technology to decrease mRNA immunogenicity, further highlighting the critical role of chemical modification technologies in developing mRNA vaccines

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Interestingly, systemic inflammation has a somewhat opposite effect on microglia-BBB interactions, as initially microglia respond to systemic inflammation by maintaining BBB integrity through direct interactions with endothelial cells