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Pink1 becomes lodged in the translocase of the outer membrane (TOM) and leads to the recruitment of Parkin, an E3 ubiquitin ligase, which polyubiquitinates proteins on the outer mitochondrial membrane and triggers the recruitment of autophagy receptors and autophagy machinery to degrade the mitochondrion (Narendra et al., 2008

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Presented for research literature review only Xu Y et al