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The marked reduction in TNF-α release may be associated with the neuroprotective power of Pyr-sulf: the capacity of Pyr-sulf to pre-condition cells, interfering with NF-κB nuclear translocation and being able to better respond to oxidative stimuli, an excitotoxicity burst or an inflammatory situation, confirms the potential of these human bioavailable (poly)phenol metabolites to mitigate in the intricate complexity of a neurodegenerative disorder