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inject PRP around the nerve to separate adhesions and deliver growth factors Aftercare: brief rest followed by gentle hip mobility exercises and physical therapy Evidence Summary – Case reports describe successful PRP hydrodissection of the LFCN with significant symptom relief – Animal models demonstrate accelerated axonal growth and increased myelin thickness with PRP application – Systematic reviews highlight PRP’s safety profile and call for controlled trials in entrapment neuropathies Advantages & Considerations Advantages – Autologous and low risk of allergy – Minimally invasive outpatient procedure – Combines mechanical hydrodissection with regenerative biology Considerations – Variability in PRP formulations (platelet concentration, leukocyte content) – Cost and insurance coverage may vary – Need for high-quality, long-term clinical trials Future Directions – Standardize PRP preparation protocols (platelet counts, leukocyte levels) – Conduct comparative trials versus corticosteroids or dextrose prolotherapy – Evaluate long-term outcomes through imaging and electrophysiology Take-Home Messages – Meralgia paresthetica is a sensory neuropathy caused by compression of the LFCN, leading to outer-thigh burning, tingling, or numbness – Most cases improve with lifestyle changes, medications, and nerve blocks – PRP hydrodissection offers a novel regenerative approach for refractory cases – Rigorous clinical trials are needed before PRP becomes a standard treatment

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Frequently Asked Questions References ClinicalTrials.gov