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Duotone aurora — cool blue brief on the left, soft violet sheet on the right for cargo details.
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Diabetic db/db mice crossed with Keap1 gene hypomorphic knockdown ( Keap1 flox/− ) mice has revealed that genetic activation of NRF2 inhibits gluconeogenesis by suppressing glucose-6-phosphatase (G6PC), fructose-1,6-bisphosphatase 1 (FBP1), phosphoenolpyruvate carboxykinase (PCK1), peroxisome proliferator-activated receptor g coactivator 1-a (PGC1a), and nuclear receptor subfamily 4, group A, member 2 (NR4A2) in the liver, thereby preventing onset of Diabetes Mellitus [83]
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