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We agree with the commenters that the rate of dual-eligible proportion is a useful proxy for socioeconomic risk, yet we note that the rate of dual-eligible proportion is not meant to capture the nuances between patients with complex pain syndromes and those with chronic conditions
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Since chronic neuroinflammation is a driving force in diabetic neuropathy, chemotherapy-induced neuropathy, and many other forms, this anti-inflammatory mechanism addresses a root cause rather than a downstream symptom
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