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However, supplementing L-carnitine helps in the hemodialysis (HD) of dialysis patients via obviating comorbidities such as decreased exercise capacity, muscle symptoms, and increased intradialytic hypotension, as well as cardiac complications (arrhythmias, reduced output, low cardiothoracic ratio)

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The induction of a ferroptosis vulnerable state with PUFA accumulation/lipid peroxidation was more evident after 5-14 days of treatment, correlating with the time required to establish a quiescent/senescent phenotype 53,54