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Along with the “bypassing key” and rapidly activated collaterals, Virchow’s triad was consistently reduced, both peripherally and centrally (Vukojevic et al., 2018

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The binding mode for folate in state II rationalizes the linkage position for nearly all folate-conjugates, as the cargo for these multifunctional molecules are almost exclusively coupled at or near the γ-carboxylate of the glutamate (28, 48–50, 64)