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Notably, the Phase I clinical data reveal that the most frequent treatment-related adverse events (TRAEs) were predominantly hematologic (e.g., neutropenia [86.8%], leukopenia [90.1%], thrombocytopenia [71.9%]) and gastrointestinal (e.g., nausea [61.2%], stomatitis [52.9%], vomiting [47.9%]), which are typical of topoisomerase I inhibitor-based ADCs and manageable with supportive care [96, 97]
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