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These diseases are caused by many endogenous (genetic, metabolic, immune, etc.) and exogenous factors (trauma, environment, lifestyle, etc.) (Mehndiratta and Aggarwal, 2021), mainly neurodegenerative and cerebrovascular diseases, which are the second leading cause of death worldwide in addition to cardiovascular diseases, including stroke Alzheimer’s disease (AD), Parkinson’s disease, and depression are the most common neurological disorders, and their pathogenesis is complex, there is no effective cure or prevention strategy, and the efficacy and side effects of related therapeutic drugs change with the prolongation of the disease

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A 2024 paper discussed the potential mechanisms underlying the reversal of AN symptoms in response to KD therapy